Tezosentan

CAS 180384-57-0 MFCD00949625

化学结构图

180384-57-0
SMILES: COC1C=CC=CC=1OC1C(=NC(=NC=1NS(=O)(=O)C1C=CC(=CN=1)C(C)C)C1C=C(N=CC=1)C1NN=NN=1)OCCO

化学属性

Mol. FormulaC27H27N9O6S
Mol. Weight605.62

别名和识别编码

Chemical NameTezosentan
CAS Number180384-57-0
Synonym N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-2-pyridinesulfonamide
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • A potent dual endothelian (ETA/ETB) receptor antagonist optimized from Bosentan (B675900).

相关文献及参考

  • Clozel, M., et al.: J. Pharmacol. Exp. Ther., 290, 840 (1999),
  • Dingemanse, J., et al.: Br. J. Clin. Pharmacol., 53, 355 (2002),
  • Schalcher, C., et al.: Am. Heart J., 142, 340 (2001),
  • [1]. Clozel M, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999 Aug;290(2):840-6.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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