Lactacystin

CAS 133343-34-7 MFCD01076525

化学结构图

133343-34-7
SMILES: CC(=O)N[C@@H](CSC(=O)[C@@]1(NC(=O)[C@H](C)[C@@H]1O)[C@@H](O)C(C)C)C(O)=O

化学属性

Mol. FormulaC15H24N2O7S
Mol. Weight376

别名和识别编码

Chemical NameLactacystin
CAS Number133343-34-7
Synonym Lactacystin N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine
MDL NumberMFCD01076525
PubChem Substance ID24896445
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Calpain and Proteasome Inhibitors, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Endoplasmic Reticulum Stress, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inh

产品应用

  • A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multic

相关文献及参考

  • [2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.
  • Fenteany, G., et al.: Proc. Natl. Acad. Sci. USA, 91, 3358 (1994),
  • Fenteany, G., et al.: Science, 268, 726 (1995),
  • [1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67.
  • [1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67.
  • [2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. L - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Proteasome inhibitor - P to Q
  1. Functional Group 官能团索引
  2. thiocarboxylic acid ester
  1. Medical Research Areas
  2. Metabolism
  3. Proteasome  (蛋白酶体)

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