1-(Tert-Butyl)-3-(p-Tolyl)-1H-Pyrazolo[3,4-d]Pyrimidin-4-Amine 1-(叔丁基)-3-(对甲苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺

CAS 172889-26-8 MFCD01076570

化学结构图

172889-26-8
SMILES: Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1

化学属性

Mol. FormulaC16H19N5
Mol. Weight281.36
Appearance Solid powder
SolubilitySoluble in DMSO

别名和识别编码

Chemical Name1-(Tert-Butyl)-3-(p-Tolyl)-1H-Pyrazolo[3,4-d]Pyrimidin-4-Amine
CAS Number172889-26-8
Synonym 1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine AGL 1872 PP1 PP1; PP 1; PP1.
MDL NumberMFCD01076570
PubChem Substance ID329819992
FormulaC16H19N5
IUPAC Name1-(tert-butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChIKeyZVPDNRVYHLRXLX-UHFFFAOYSA-N
InChIInChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
Canonical SMILESNC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(C)C=C3)=NC=N1
Chemical Name Translation1-(叔丁基)-3-(对甲苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺
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分类

  • Nucleotides
  • {SNA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, Pfizer Compounds, v-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Src)
  • Heterocycles
  • Bases & Related Reagent
  • Protein Kinase Inhibitors and Activators
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,

产品应用

  • PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. PP1 effectively blocks TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells. PP1 blocks TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors. PP1 was also found to potentiate tumor-suppressive effect of connexin 32 gene in renal cancer cells.

相关文献及参考

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安全信息

GHS Symbol
Precautionary statements
  • P301+P310
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word Danger
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Pfizer Compounds - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. Stem Cells / Wnt
  3. TGF-beta/Smad
  1. Medical Research Areas
  2. TGF-beta /Smad
  3. TGF-beta

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