2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone 2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮

CAS 2854-32-2 MFCD01317813

化学结构图

2854-32-2
SMILES: COc1ccc2c(c1)c(CC(=O)N1CCOCC1)c(C)n2C(=O)c1ccc(Cl)cc1

化学属性

Mol. FormulaC23H23ClN2O4
Mol. Weight426.93
Density1.31
SolubilityDMSO 22 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

别名和识别编码

Chemical Name2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone
Synonym 1H-Indole, 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole; 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-[(morpholinocarbonyl)methyl]-indole; 4-((2-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl)acetyl)morpholine BML 190 BML-190 BML190 Indomethacin Morpholinylamide;Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)- Indomethacin morpholinylamide indomethacin morpholinylamide
MDL NumberMFCD01317813
CAS Number2854-32-2
Chemical Name Translation2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮
Wiswesser Line NotationT56 BNJ BVR DG& C1 GO1 D1V- AT6N DOTJ
Beilstein Registry Number1230853
InChIKeyOOKFHWWAUUITQR-UHFFFAOYSA-N
LabNetwork Molecule IDLN00190126
PubChem Substance ID2415
InChIInChI=1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3
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分类

  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics G-M, Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, I, Neurobiology, Neuroscience, Pharmacologicals

相关文献及参考

  • [2]. Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786.
  • [3]. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.
  • [1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutica
  • [1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences (2010), 41(1), 163-172.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 储存温度-20°C
RTECSQD9930000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   114,309,1975

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. I - Bioactive Small Molecules
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Cannabinoid Receptor  (大麻素受体)

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