Nuciferine (R)-1,2-二甲氧基-6-甲基-5,6,6a,7-四氢-4H-二苯并[de,g]喹啉
CAS 475-83-2 MFCD01664592
化学结构图
SMILES: COc1cc2c3c(c1OC)-c1ccccc1C[C@H]3N(C)CC2
化学属性
| Mol. Formula | C19 H21 N O2 |
|---|---|
| Mol. Weight | 295.38 |
| Density | 1.15 |
别名和识别编码
| Chemical Name | (R)-1,2-Dimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline |
|---|---|
| Synonym | (R)-5,6,6a,7-Trtrahydro-1,2-dimethoxy-6-methyl-4H-Dibenzo[de,g]quinoline, 1,2-Dimethoxy-6aβ-aporphine, Nuciferine, (-)-Nuciferine, (R)-1,2-Dimethoxyaporphine (R)-Nuciferine 1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, Nuciferin {} {} {} {} {} {} {} {} {} {PubChem} nuciferine, (S)-isomer {} {} {} {} {} {} {} {} {} {} {PubChem} nuciferine, (+-)-isomer {} {} {} {} {} {} {} {} {} {} {} {PubChem} nuciferine {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} l-5,6-dimethoxyaporphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} l-5,6-dimethoxyaporphine 荷叶碱 |
| CAS Number | 475-83-2 |
| Chemical Name Translation | (R)-1,2-二甲氧基-6-甲基-5,6,6a,7-四氢-4H-二苯并[de,g]喹啉 |
| Wiswesser Line Notation | T C6666 1A Q KN&TT&J K1 PO1 QO1 |
| LabNetwork Molecule ID | LN01301867 |
| PubChem Substance ID | 10146 |
| InChI | InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1 |
| MDL Number | MFCD01664592 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
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产品应用
- 荷叶碱能促进脂肪的分解，同时具有利尿通便、通肠毒、降脂除油、清暑解热等作用，能明显降低血清中甘油三醇和胆固醇含量，具有调节血脂的保健作用。
相关文献及参考
- [2]. Chan JD, et al. Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):364-370.
- [1]. Farrell MS, et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602.
- [1]. Farrell MS, et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602.
- [2]. Chan JD, et al. Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):364-370.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Sense Organs and Special Senses (Eye) - ptosis REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 197,261,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Nutritional and Gross Metabolic - body temperature decrease Behavioral - convulsions or effect on seizure threshold REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 197,261,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 83 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,813,1972
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310
- P301+P316
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
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