3-((4-Amino-2-Methylpyrimidin-5-Yl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride 3-((4-氨基-2-甲基嘧啶-5-基)甲基)-1-(2-氯乙基)-1-亚硝脲盐酸盐

CAS 55661-38-6 MFCD01676942

化学结构图

55661-38-6
SMILES: Cl.CC1N=CC(CNC(=O)N(CCCl)N=O)=C(N)N=1

化学属性

Mol. FormulaC9H13ClN6O2·HCl
Mol. Weight309.15

别名和识别编码

Chemical Name3-((4-Amino-2-Methylpyrimidin-5-Yl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride
Synonym 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea ACNU N'-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea hydrochloride Nimustine hydrochloride
MDL NumberMFCD01676942
PubChem Substance ID87560181
CAS Number55661-38-6
Reaxys-RN4220350
Merck Number6553
Chemical Name Translation3-((4-氨基-2-甲基嘧啶-5-基)甲基)-1-(2-氯乙基)-1-亚硝脲盐酸盐
Wiswesser Line NotationT6N CNJ B1 DZ E1MVNNO&2G
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分类

  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, DNA Intercalators and Crosslinkers, DNA metabolism, N, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism, N

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P301+P310
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
RTECSYR8450000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
Hazard Class6.1
UN Number 2811
Packing GroupIII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,884,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 83 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   37XLA2 "Current Chemotherapy, Proceedings of the 10th International Congress
   of Chemotherapy, Zurich, 1977," Siegenthaler, W., and R. Luethy, eds., 2
   vols., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1233,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,884,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,49,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Bone marrow
DOSE/DURATION           : 100 umol/L
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 3200 ug/L
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33,455,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Bone marrow
DOSE/DURATION           : 9200 ug/L
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33,455,1985

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   AMKUDT Acta Medica Kinki University.  (Kinki Univ. Medical Assoc., 380
   Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan)   V.1-    1976-
   Volume(issue)/page/year: 11,57,1986

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,34

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TJADAB Teratology, The Internation

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 13 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 29,118,1977

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Ro

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 38,553,1988

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. N - Bioactive Small Molecules

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