Neferine 4-(((S)-6,7-二甲氧基-2-甲基-1,2,3,4-四氢异喹啉-1-基)甲基)-2-(((R)-6-甲氧基-1-(4-甲氧基苄基)-2-甲基-1,2,3,4-四氢异喹啉-7-基)氧基)苯酚

CAS 2292-16-2 MFCD01707128

化学结构图

2292-16-2
SMILES: COc1ccc(C[C@@H]2c3cc(Oc4cc(C[C@H]5c6cc(OC)c(OC)cc6CCN5C)ccc4O)c(OC)cc3CCN2C)cc1

化学属性

Mol. FormulaC38H44N2O6
Mol. Weight625
Density1.185
Boiling Point
Melting Point

别名和识别编码

Chemical NameNeferine
Synonym (-)-Neferine 4′′-O-Methylliensinine 4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol Methylliensinine Neferin Neferine neferine 甲基莲心碱
CAS Number2292-16-2
Chemical Name Translation4-(((S)-6,7-二甲氧基-2-甲基-1,2,3,4-四氢异喹啉-1-基)甲基)-2-(((R)-6-甲氧基-1-(4-甲氧基苄基)-2-甲基-1,2,3,4-四氢异喹啉-7-基)氧基)苯酚
Beilstein Registry Number1523459
InChIKeyMIBATSHDJRIUJK-ROJLCIKYSA-N
PubChem Substance ID159654
InChIInChI=1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1
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EC Number
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Chaperonins and Heat Shock Proteins, Heat Shock and Related Proteins, Kinase/Phosphatase Biology, MAPK-Activated Protein Kinase (MAPKAP Kinase), New Products, Nitric Oxide and Cell Stress, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

相关文献及参考

  • Zhang, X., et al., Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur. J. Pharmacol. 677 , 47-54, (2012)
  • Peng, Z.Y., et al., Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway. Can. J. Physiol. Pharmacol. 89 , 289-294, (2011)
  • Li, X.C., et al., Neferine inhibits angiotensin II-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1. Acta Pharmacol. Sin. 31 , 679-686, (2010)

安全信息

RTECSSM9495000
WGK Germany3
Storage condition 储存温度2-8℃
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 19,217,1988

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系列性分类


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