Potassium (2R,5R,Z)-3-(2-Hydroxyethylidene)-7-Oxo-4-Oxa-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate (2R,5R,Z)-3-(2-羟基亚乙基)-7-氧代-4-氧杂-1-氮杂双环[3.2.0]庚烷-2-羧酸钾

CAS 61177-45-5 MFCD01710901

化学结构图

61177-45-5
SMILES: [K+].[O-]C(=O)[C@@H]1/C(=C/CO)/O[C@H]2CC(=O)N12 |&1:4,10|

化学属性

Mol. FormulaC8
Mol. Weight237

别名和识别编码

Chemical NamePotassium (2R,5R,Z)-3-(2-Hydroxyethylidene)-7-Oxo-4-Oxa-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
Synonym 棒酸钾 Potassium clavulanate 克拉维酸钾 BRL 14151K
MDL NumberMFCD01710901
PubChem Substance ID24860237
CAS Number61177-45-5
EC Number262-640-9
Chemical Name Translation(2R,5R,Z)-3-(2-羟基亚乙基)-7-氧代-4-氧杂-1-氮杂双环[3.2.0]庚烷-2-羧酸钾
LabNetwork Molecule IDLN00202453
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分类

  • {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Bactericidal, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, N-P, Pharmaceuticals, Illicit Drugs & Alcohol, Principle, beta-Lactam Structure, 农残和代谢标准品, 分析/色谱, 按照字母排序
  • Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Antibiotics, Bactericidal, Bacteriostatic, Chemical Structure, Chromatography, Clinical Standards, Environmental Standards,

安全信息

RTECSRN6802700
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+P340
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P235+P410
  • P231+P232
  • P342+P311
Signal word Danger Warning
Hazard statements
  • H228 Flammable solid 易燃固体
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H252 Self-heating in large quantities; may catch fire 自我释放大量的热；可能着火。
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Risk Statements
  • R14 Reacts violently with water 遇水会猛烈反应
  • R36 Irritating to eyes 刺激眼睛
  • R11 Highly flammable 非常易燃
  • R44 Risk of explosion if heated under confinement 密封下加热有爆炸危险
  • R42/43
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S8 Keep container dry 保持容器干燥；
Hazard Codes F,Xn 
{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 326 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   34(Suppl 4),69,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   34(Suppl 4),69,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1680 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   34(Suppl 4),69,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7936 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   31(Suppl 2),113,1983

{hazar

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1650 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   34(Suppl 4),69,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   31(Suppl 2),238,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   31(Suppl 2),238,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11200 mg/kg
SEX/DURATION            : female 15-21 day(s) after conception
                          lactating female

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PON - PT - P
  1. Functional Group 官能团索引
  2. carboxylic acid salt
  1. Functional Group 官能团索引
  2. enol ether
  1. Functional Group 官能团索引
  2. hemiaminal

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