N-Demethyl Rifampin N-去甲利福平
CAS 13292-45-0 MFCD01729343
化学结构图
SMILES: CO[C@H]1C=CO[C@@]2(C)OC3=C(C4=C(C(O)=C(NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(/C=N/N1CCNCC1)=C4O)C(O)=C3C)C2=O |c:20,51,56,t:3,22|
化学属性
| Mol. Formula | C42H56N4O12 |
|---|---|
| Mol. Weight | 809 |
别名和识别编码
| Chemical Name | 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-(N-1-piperazinylfo rmimidoyl)-, 21- acetate |
|---|---|
| CAS Number | 13292-45-0 |
| Synonym | 4-N-Demethylrifampicin Demethylrifampicin Rifampicin AF/A 3-((1-Piperazinylimino)methyl)rifampicin Rifampicin, 3-((1-piperazinylimino)methyl)- N-Demethylrifampin N-Demethylrifampicin 3-Piperazinoiminomethyl Rifamycin SV AF/AP N-Demethyl-rifampicin Rifampicin AF/AP NSC 143416 3-[(1-Piperazinylimino)methyl]-rifamycin |
| Chemical Name Translation | N-去甲利福平 |
| Beilstein Registry Number | 0603769 |
| MDL Number |
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分类
- Chiral Reagents
- Heterocycles
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- N-Demethyl Rifampin is a metabolite of Rifampicin (R508000).
相关文献及参考
- Marsili, L., et al.: J. Antibiot., 37, 1209
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 695 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 100 mg/L REFERENCE : BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 60,96,1974
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