Vindoline 文多灵
CAS 2182-14-1 MFCD01744432
化学结构图
SMILES: CCC12C=CCN3CCC4(c5ccc(OC)cc5N(C)C4C(O)(C(=O)OC)C1OC(C)=O)C32
化学属性
| Mol. Formula | C25 H32 N2 O6 |
|---|---|
| Mol. Weight | 456.53 |
| Density | 1.33 |
| Melting Point | 162-1640C |
| Boiling Point | |
| Flash Point | - |
别名和识别编码
| Chemical Name | Vindoline |
|---|---|
| CAS Number | 2182-14-1 |
| Synonym | (-)-Vindoline (2?,3?,4?,5?,12?,19?)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic acid methyl ester Methyl (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylate NSC 91994 Vindolin Vindoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
| MDL Number | - |
| EC Number | 218-558-0 |
| Chemical Name Translation | 文多灵 |
| Wiswesser Line Notation | T C6 B5665 2AB S BX IN QN NU JH&&TTTJ FO1 I1 KVO1 KQLOV1 M2 |
| PubChem Substance ID | 260535 |
| InChI | InChI=1S/C25H32N2O6/c1-6-23-10-7-12-27-13-11-24(19(23)27)17-9-8-16(31-4)14-18(17)26(3)20(24)25(30,22(29)32-5)21(23)33-15(2)28/h7-10,14,19-21,30H,6,11-13H2,1-5H3/t19-,20+,21+,23+,24+,25-/m0/s1 |
| LabNetwork Molecule ID | LN01326585 |
| Canonical SMILES | - |
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分类
- {SNA} Metabolic Pathways, Terpenoid Metabolism, Terpenoids, 代谢组学, 细胞生物学
- {SNA} Cell Biology, Metabolic Pathways, Metabolomics, Terpenoid Metabolism, Terpenoids
- {SNA} Terpenoids, 代谢组学, 代谢通路, 细胞生物学, 萜类代谢
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A novel antitumor agent.
相关文献及参考
- Altstadt, T., et al.: J. Med. Chem., 44, 4577 (2001),
- Baloglu, E., et al.: Bioorg. Med. Chem., 11, 1557 (2003),
- Distefano, M., et al.: Int. J. Cancer, 72, 844 (1997),
- Merck: 14,9988
- [1]. Prakash V, et al. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30(3):873-80.
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P203
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P308+P313
- P318
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement REFERENCE : 33GVAL "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975 Volume(issue)/page/year: -,73,1975
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