Nitisinone 尼替西农
CAS 104206-65-7 MFCD01752192
化学结构图
SMILES: O=C1CCCC(=O)C1C(=O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]
化学属性
| Mol. Formula | C14H10F3NO5 |
|---|---|
| Mol. Weight | 329 |
别名和识别编码
| Chemical Name | Nitisinone |
|---|---|
| CAS Number | 104206-65-7 |
| Synonym | 2-(2-Nitro-4-trifluorobenzoyl)-1,3-cyclohexanedione 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione 2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione 2-(2-硝基-4-三氟甲基苯甲酰基)-1,3-环己二酮 2-(2-硝基-4-三氟甲基苯甲酰基)-1,3-环己二酮 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione NTBC Nitisone SC 0735 2-[2-Nitro-4-(trifluoromethyl)benzoyl]- 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione NTBC NTBC cpd Nitisinone Nitisone Orfadin SC 0735 nitisinone |
| MDL Number | MFCD01752192 |
| PubChem Substance ID | 115355 |
| Chemical Name Translation | 尼替西农 |
| InChI | InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2 |
| LabNetwork Molecule ID | LN00190163 |
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分类
- {SNA} Antioxidants and Cytoprotectants, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents
- Aromatics
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Cell Stress, N, Nitric Oxide and Cell Stress,
产品应用
- Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is u
相关文献及参考
- [2]. Santra, S. and U. Baumann, Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother, 2008. 9(7): p. 1229-36.
- Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995),
- Lindstedt, S., et al.: Lancet, 340, 813 (1992),
- Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),
- [1]. Suwannarat, P., et al., Use of nitisinone in patients with alkaptonuria. Metabolism, 2005. 54(6): p. 719-28.
- [1]. Suwannarat, P., et al., Use of nitisinone in patients with alkaptonuria. Metabolism, 2005. 54(6): p. 719-28.
- [2]. Santra, S. and U. Baumann, Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother, 2008. 9(7): p. 1229-36.
安全信息
- H302 Harmful if swallowed 吞食有害
- H311 Toxic in contact with skin 皮肤接触中毒
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P302+P352
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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