2-(Di-t-butylphosphino)biphenyl 2-(二叔丁基膦)联苯

CAS 224311-51-7 MFCD01862440

化学结构图

224311-51-7
SMILES: CC(C)(C)P(C1=CC=CC=C1C1C=CC=CC=1)C(C)(C)C

化学属性

Mol. FormulaC20H27P
Mol. Weight298.41
Melting Point85.0 to 89.0 deg-C
TSCANo
SolubilitySoluble in toluene. Insoluble in water.
Stability对空气敏感
Appearance white xtl.
Density1.000000

别名和识别编码

Chemical Name2-(Di-t-butylphosphino)biphenyl
CAS Number224311-51-7
Alfabeta NameDIBUTYLPHOSPHINOBIPHENYL T2()---
MDL NumberMFCD01862440
Synonym (2-Biphenylyl)-di-tert-butylphosphine (2-Biphenylyl)di-tert-butylphosphine, JohnPhos (2-联苯基)二-叔丁基膦 2-(二-叔-丁基膦基)联苯 2-(二叔丁基膦)联苯 JohnPhos (2-联苯基)二-叔丁基膦 2-(二-叔-丁基膦基)联苯 JohnPhos (2-联苯基)二叔丁基膦 (2-联苯基)二叔丁基膦; (2-联苯基)二-叔丁基膦;2-(二-叔-丁基膦基)联苯 2-(二叔丁基膦)联苯
PubChem Substance ID87558786
Beilstein Registry Number8322131
EC Number000-000-0
Reaxys-RN8322131
Chemical Name Translation2-(二叔丁基膦)联苯
LabNetwork Molecule IDLN00118638
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分类

  • {SNA} Buchwald Ligands, Buchwald Ligands and Complexes, Catalysis and Inorganic Chemistry, Chemical Synthesis, Cross-Coupling, Phosphine Compounds
  • {SNA} Buchwald Ligands, Buchwald Ligands and Complexes, Catalysis and Inorganic Chemistry, Chemical Synthesis, Cross-Coupling, Ligands, Phosphine Compounds
  • {SNA} Buchwald Ligands, Buchwald Ligands, Buchwald Ligands and Complexes, Catalysis and Inorganic Chemistry, Chemical Synthesis, Cross-Coupling, Phosphine Compounds

产品应用

  • 用于 α,α-双取代-3-噻吩甲醇经 Pd 催化的 2,3-二芳基化使 C-H 和 C-C 键断裂的大位阻膦配体。
  • 用于芳基卤和芳基三氟甲磺酸酯胺化的配体。
  • 用于钯催化 Stille 交叉偶联反应的大位阻联芳膦配体。

相关文献及参考

  • Hindered ligand, employed by Buchwald and others in otherwise difficult coupling reactions. For use in Suzuki coupling of boronic acids with aryl chlorides, see: Angew. Chem. Int. Ed., 38, 2413 (1999); J. Am. Chem. Soc., 121, 9550 (1999). Also promotes the Pd-catalyzed coupling of silylamines with aryl halides to give N,N-dialkyl anilines: Chem. Commun., 1976 (2004).

安全信息

Warnings AIR SENSITIVE
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Signal word Warning
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
GHS Symbol
Storage condition 充氩保存

其他信息

  • A ligand utilized in amination of aryl halides and aryl triflates.

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Phosphorus Compounds 磷化合物
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  4. Buchwald Ligands Buchwald 膦配体
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  4. Buchwald Ligands Buchwald 膦配体
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  4. Phosphine Ligands 膦配体
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Cross-Coupling 交叉偶联
  4. Basic Phosphine Ligands
  1. Functional Group 官能团索引
  2. phosphine
  1. Buchwald Precatalysts & Ligands
  2. Phosphorus
  1. Phosphine
  2. Phosphorus
  1. Ligands
  2. Phosphorus
  1. Buchwald Precatalysts & Ligands
  2. 96-5500 Buchwald Biaryl Phosphine Ligand Master Kit for Aromatic Carbon-Heteroatom Bond Formation, Suzuki Coupling and Negishi Cross-coupling
  1. Ligands
  2. 96-5500 Buchwald Biaryl Phosphine Ligand Master Kit for Aromatic Carbon-Heteroatom Bond Formation, Suzuki Coupling and Negishi Cross-coupling
  1. Phosphine
  2. 96-5500 Buchwald Biaryl Phosphine Ligand Master Kit for Aromatic Carbon-Heteroatom Bond Formation, Suzuki Coupling and Negishi Cross-coupling
  1. Buchwald Precatalysts & Ligands
  2. 96-5490 Buchwald Biaryl Phosphine Ligand Mini Kit 2 for Aromatic Carbon-Heteroatom Bond Formation, Suzuki Coupling and Negishi Cross-coupling
  1. Ligands
  2. 96-5490 Buchwald Biaryl Phosphine Ligand Mini Kit 2 for Aromatic Carbon-Heteroatom Bond Formation, Suzuki Coupling and Negishi Cross-coupling
  1. Phosphine
  2. 96-5490 Buchwald Biaryl Phosphine Ligand Mini Kit 2 for Aromatic Carbon-Heteroatom Bond Formation, Suzuki Coupling and Negishi Cross-coupling
  1. Ligands
  2. 96-1650 Phosphine Ligand Kit for Palladium-Catalyzed Carbon-Carbon and Carbon-Heteroatom Bond Formation
  1. Phosphine
  2. 96-1650 Phosphine Ligand Kit for Palladium-Catalyzed Carbon-Carbon and Carbon-Heteroatom Bond Formation
  1. Ligands
  2. Phosphorus
  3. Buckwad Ligands/偶联C-N键生成

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