Epothilone B 埃博霉素B
CAS 152044-54-7 MFCD02101921
化学结构图
SMILES: CC1(C)[C@@H](O)CC(=O)O[C@@H](C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O)/C(/C)=C/C1=CSC(C)=N1
化学属性
| Mol. Formula | C27H41NO6S |
|---|---|
| Mol. Weight | 507.68 |
别名和识别编码
| Chemical Name | Epothilone B |
|---|---|
| CAS Number | 152044-54-7 |
| Synonym | (-)-Epothilone B (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione EPO906 EpoB Patupilone |
| MDL Number | MFCD02101921 |
| PubChem Substance ID | 24724475 |
| Chemical Name Translation | 埃博霉素B |
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分类
- Inhibitors
- Sulfur & Selenium Compounds
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience, E
- {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, E, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
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相关文献及参考
- [2]. Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43.
- [3]. Oehler C, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13(9):1000-10.
- Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995),
- Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001),
- [1]. Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6.
- [1]. Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6.
- [2]. Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 20
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