AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation. 2-(3-溴-5-(叔丁基)-4-羟基亚苄基)丙二腈
CAS 65678-07-1 MFCD02179365
化学结构图
SMILES: CC(C)(C)c1cc(C=C(C#N)C#N)cc(Br)c1O
化学属性
| Mol. Formula | C14H13BrN2O |
|---|---|
| Mol. Weight | 305 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation. |
|---|---|
| MDL Number | MFCD02179365 |
| Chemical Name Translation | 2-(3-溴-5-(叔丁基)-4-羟基亚苄基)丙二腈 |
| Formula | C14H13BrN2O |
| Synonym | AG1024; AG-1024; AG 1024. Tyrphostin. |
| IUPAC Name | 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile |
| InChIKey | ABBADGFSRBWENF-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3 |
| Canonical SMILES | N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(Br)=C1 |
| CAS Number | 65678-07-1 |
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分类
- {SNA} Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Insulin-Like Growth Factor Receptor (IGF1R and IGf2R), Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
产品应用
- AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.
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