Cd-437 6-(3-(1-金刚烷基)-4-羟基苯基)-2-萘甲酸
CAS 125316-60-1 MFCD03106506
化学结构图
SMILES: OC1C=CC(=CC=1[C@@]12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C1=CC2C=CC(=CC=2C=C1)C(O)=O |&1:7,9,11,14|
化学属性
| Mol. Formula | C27H26O3 |
|---|---|
| Mol. Weight | 398.49 |
| Melting Point | 271.6-276 °C |
别名和识别编码
| Chemical Name | Cd-437 |
|---|---|
| CAS Number | 125316-60-1 |
| Synonym | 6-(4-Hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic acid 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid AHPN 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid AHPN CD 437 CD 437/AHPN CD437 |
| MDL Number | MFCD03106506 |
| PubChem Substance ID | 24724445 |
| Chemical Name Translation | 6-(3-(1-金刚烷基)-4-羟基苯基)-2-萘甲酸 |
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分类
- Pharmaceuticals
- {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, C-CH, Gene Regulation and Expression, PPAR and RXR Regulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Aromatics
- Intermediates & Fine Chemicals
- {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
产品应用
- An intermediate in the preparation of Adapalene derivatives.
相关文献及参考
- [2]. Schadendorf D, et al. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo. J Cell Biol. 1996 Dec;135(6 Pt 2):1889-98.
- Virtanen, M., et al.: Exper. Dermatol., 19, 674 (2010),
- Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),
- [1]. Li Y, et al. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol. 1998 Aug;18(8):4719-31.
- [1]. Li Y, et al. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol. 1998 Aug;18(8):4719-31.
- [2]. Schadendorf D, et al. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo. J Cell Biol. 1996 Dec;135(6 Pt 2):1889-98.
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 15 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,158,1996
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 15 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,158,1996
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