VAS 2870 2-((3-苄基-3H- [1,2,3]三唑并[4,5-d]嘧啶-7-基)硫基)苯并[d]恶唑

CAS 722456-31-7 MFCD03407188

化学结构图

722456-31-7
SMILES: C(C1C=CC=CC=1)N1N=NC2C(=NC=NC1=2)SC1=NC2C=CC=CC=2O1

化学属性

Mol. FormulaC18H12N6OS
Mol. Weight360.39

别名和识别编码

Chemical NameVAS 2870
Synonym 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine VAS 2870 VAS-2870 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine VAS 2870 VAS-2870 VAS2870
MDL NumberMFCD03407188
Chemical Name Translation2-((3-苄基-3H- [1,2,3]三唑并[4,5-d]嘧啶-7-基)硫基)苯并[d]恶唑
PubChem Substance ID329825281
CAS Number722456-31-7
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Nitric Oxide Metabolism, Nitric Oxide Synthase Regulators, Nitric Oxide and Cell Stress
  • {SNA} Bioactive Small Molecule Alphabetical Index, Nitric Oxide Synthase Regulators, V, 一氧化氮代谢, 一氧化氮和细胞应激, 生物活性小分子, 细胞信号转导和神经科学,

相关文献及参考

  • [2]. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.
  • [1]. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41.
  • [1]. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41.
  • [2]. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Nitric Oxide Metabolism - Nitric Oxide and Cell Stress
  6. Nitric Oxide Synthase Regulators - Nitric Oxide Metabolism
  1. Medical Research Areas
  2. Metabolism
  3. NADPH Oxidase  (NADPH氧化酶)

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