Tamoxifen

CAS 15917-65-4 MFCD03423594

化学结构图

15917-65-4
SMILES:

化学属性

Mol. FormulaC25H27NO·HCl
Mol. Weight393.95
Melting Point97-98 ºC

别名和识别编码

Chemical NameN-Desmethyltamoxifen HCl
Synonym (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine ICI 55,548 ICI 55,548 trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
MDL NumberMFCD03423594
CAS Number15917-65-4
EC Number234-118-0
PubChem Substance ID329798889
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, D-DIF, Hormones, Kinase/Phosphatase Biology, Other Steroid Products, Protein Kinase C (PKC), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Steroid Hormones
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, D-DIF, Hormones, Kinase/Phosphatase Biology, Other Steroid Products, Protein Kinase C (PKC), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors,
  • {SNA} Bioactive Small Molecule Alphabetical Index,
  • {SNA} Bioactive Small Molecule Alphab

相关文献及参考

  • Gjerde, J., et al., Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann. Oncol. 19 , 56-61, (2008) 摘要
  • Jordan, V.C., New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer. Steroids 72 , 829-842, (2007) 摘要
  • Sane, R.S., et al., Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells. Drug Metab. Dispos. 36 , 946-954, (2008) 摘要

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P308+P313
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
Signal word Danger
Hazard statements
  • H350 May cause cancer 可能致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T,N T
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R60 May impair fertility 可能降低生殖能力
  • R64 May cause harm to breast-fed babies 可能导致伤害脯乳期婴儿
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R50/53

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Other Steroid Products - Steroid Hormones
  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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