(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol (Z)-3,4,5,4,-四甲氧基-3-羟基二苯乙烯

CAS 117048-59-6 MFCD03453309

化学结构图

117048-59-6
SMILES: COC1C=C(C=C(OC)C=1OC)/C=C\C1=CC(O)=C(C=C1)OC

化学属性

Mol. FormulaC18H20O5
Mol. Weight316
Density1.422
Melting Point81-85

别名和识别编码

Chemical Name(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol
CAS Number117048-59-6
Synonym (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol 1-(3,4,5-Trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl) ethane 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol CS-A4 Combretastatin A-4
EC Number250-023-7
Beilstein Registry Number4786976
MDL NumberMFCD03453309
Chemical Name Translation(Z)-3,4,5,4,-四甲氧基-3-羟基二苯乙烯
Reaxys-RN4786976
Merck Number2494
PubChem Substance ID253660156
LabNetwork Molecule IDLN00336954
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分类

  • {SNA} Apoptosis Inducers, Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, CI-CZ, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis Inducers, Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, CI-CY

产品应用

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相关文献及参考

  • [2]. Signoretto E, et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P). Cell Physiol Biochem. 2016;38(3):969-8
  • [3]. Zhu J, et al. Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma. J Biomed Nanotechnol. 2015 Jun;11(6):997-1006.
  • [4]. Yao N, et al. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. Tumour Biol. 2015 Nov;36(11):8499-510
  • Hamel, E., and Lin, C.M.: Biochem. Pharmacol., 32, 3863 (1983),
  • [1]. Tochinai R, et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71.
  • [1]. Tochinai R, et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71.
  • [2]. Signoretto E, et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Di

安全信息

Signal word Danger
GHS Symbol
WGK Germany2
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P305+P351+P338
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
  • H301+H311+H331
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes 6.1 T
Storage condition <;0 <0°C
Packing GroupIII
UN Number 2811

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. CI-CY - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inhibitors - Apoptosis and Cell Cycle
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers - Oxygen Compounds
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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