Coptisine 黄连碱, 来源于黄连

CAS 3486-66-6 MFCD03792689

化学结构图

3486-66-6
SMILES: c1c2c(cc3c1OCO3)-c1cc3ccc4c(c3c[n+]1CC2)OCO4

化学属性

Mol. FormulaC19H14NO4
Mol. Weight320

别名和识别编码

Chemical NameCoptisine
Synonym 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium 7,8,13,13a-tetradehydro-2,3-9,10-bis(methylenedioxy)berbinium Bis(methylenedioxy)protoberberine chloride, Coptisine chloride coptisine coptisine chloride 小檗碱
CAS Number3486-66-6
Chemical Name Translation黄连碱, 来源于黄连
LabNetwork Molecule IDLN01343175
PubChem Substance ID72322
InChIInChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1
MDL NumberMFCD03792689
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相关文献及参考

  • [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.
  • [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.
  • [1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.
  • [1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.
  • [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.
  • [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated a

安全信息

GHS Symbol
Signal word Warning
WGK Germany3
Precautionary statements
  • P301+P312+P330

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Indoleamine 2,3-Dioxygenase (IDO)  (吲哚胺 2,3 双加氧酶)

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