2-Furoyl-LIGRLO-amide trifluoroacetate salt

CAS 729589-58-6 MFCD03821022

化学结构图

729589-58-6
SMILES: CC1C=C(C)C2C(N)=C(SC=2N=1)C(=O)NCC1C=CC(Cl)=CC=1

化学属性

Mol. FormulaC36H63N11O8· xC2HF3O2
Mol. Weight777.95 (free base basis)

别名和识别编码

Chemical Name2-Furoyl-LIGRLO-amide trifluoroacetate salt
Synonym 2-Furoyl-LIGRLO-amide trifluoroacetate salt 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt 2-Fly 2-f-LIGRLO-NH2 2-fAP 2fLI f-LIGRLO-NH2
MDL NumberMFCD03821022
PubChem Substance ID329799702
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics
  • {SNA} Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87.
  • [3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol
  • [1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.
  • [1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.
  • [2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87.
  • [3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J I

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. Immunomodulators and Antibiotics - Immune System Regulation
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Protease-Activated Receptor (PAR)  (蛋白酶激活受体)

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