Norgestimate 炔诺肟酯

CAS 35189-28-7 MFCD35189287

化学结构图

35189-28-7
SMILES: CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=C/C(/CC[C@@H]4[C@@H]3CC[C@@]12CC)=N/O)C#C

化学属性

Mol. Weight369.55
Mol. FormulaC23H31NO3

别名和识别编码

CAS Number35189-28-7
Chemical NameNorgestimate
Synonym (17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime Dexnorgestrel acetime (17?)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-Oxime (17-alpha)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one
InChIKeyKIQQMECNKUGGKA-NMYWJIRASA-N
Chemical Name Translation炔诺肟酯
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, Steroid Hormones

产品应用

  • Progestogen. In combination with estrogen as oral contraceptive.

相关文献及参考

  • Hahn, D.W., et al.: Contraception, 16, 541 (1977),
  • Weintraub, H.S., et al.: J. Pharm. Sci., 67, 1406 (1978),
  • Liu, L., et al., Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo . Endocrinology 151 , 5782-5794, (2010)
  • Schmitt-Hoffmann, A.H., et al, Influence of alitretinoin on the pharmacokinetics of the oral contraceptive ethinyl estradiol/norgestimate. Clin. Exp. Dermatol. 36 Suppl 2 , 4-11, (2011)
  • Fazio, G., et al., Protrhombotic effects of contraceptives. Curr. Pharm. Des. 16 , 3490-3496, (2010)

安全信息

RTECSJF7976000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 16,541,1977

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Progesterone - Steroid Hormones

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