Degarelix 地加瑞克
CAS 214766-78-6 MFCD05860888
化学结构图
SMILES: CC(=O)N[C@H](CC1C=C2C=CC=CC2=CC=1)C(=O)N[C@H](CC1C=CC(Cl)=CC=1)C(=O)N[C@H](CC1C=NC=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1C=CC(=CC=1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@H](CC1C=CC(=CC=1)NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
化学属性
| Mol. Formula | C82H103ClN18O16 |
|---|---|
| Mol. Weight | 1632.28 |
别名和识别编码
| Chemical Name | Degarelix |
|---|---|
| Chemical Name Translation | 地加瑞克 |
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相关文献及参考
- [2]. Sakai M, et al. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonistdegarelix on human prostate cell growth. PLoS One. 2015 Mar 26;10(3):e0120670.
- [3]. Broqua P, et al. Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormoneantagonist: degarelix. J Pharmacol Exp Ther. 2002 Apr;301(1):95-102.
- [4]. Sonesson A, et al. Metabolite profiles of degarelix, a new gonadotropin-releasing hormone receptor antagonist, in rat, dog, and monkey. Drug Metab Dispos. 2011 Oct;39(10):1895-903.
- [1]. Rick FG, et al. An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer. Onco Targets Ther. 2013 Apr 16;6:391-402.
- [1]. Rick FG, et al. An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer. Onco Targets Ther. 2013 Apr 16;6:391-402.
- [2]. Sakai M, et al. In search of the molecular mechanisms mediating
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