GW4869 dihydrochloride 4′,4′′-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐

CAS 6823-69-4 MFCD06411564

化学结构图

6823-69-4
SMILES: Cl.Cl.O=C(C=Cc1ccc(C=CC(=O)Nc2ccc(C3=NCCN3)cc2)cc1)Nc1ccc(C2=NCCN2)cc1

化学属性

Mol. FormulaC30H28N6O2· 2HCl
Mol. Weight577.50
Melting Point>;300 °C

别名和识别编码

Chemical NameP-Benzenediacrylanilide, 4′,4′′-Di-2-Imidazolin-2-Yl-, Dihydrochloride
MDL NumberMFCD06411564
CAS Number6823-69-4
Chemical Name Translation4′,4′′-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐
Synonym GW 4869 GW-4869 GW4869 N,N'-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3'-p-phenylene-bis-acrylamide dihydrochloride
PubChem Substance ID16078967
LabNetwork Molecule IDLN03243792
InChIInChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;;
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分类

  • {SNA} Approved Therapeutics/Drug Candidates,
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G, GlaxoSmithKline, R to Z, Sphingomyelinase (neutral), 生物活性小分子, 细胞生物学,

相关文献及参考

  • [2]. Essandoh K, et al. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochim Biophys Acta. 2015 Nov;1852(11):2362-71.
  • [3]. Chen L, et al. Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes. FEBS Lett. 2016 Dec;590(23):4263-4274.
  • [4]. Nakamura H, et al. Sphingomyelin Regulates the Activity of Secretory Phospholipase A2 in the Plasma Membrane. J Cell Biochem. 2015 Sep;116(9):1898-907.
  • [1]. Luberto C, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutralsphingomyelinase. J Biol Chem. 2002 Oct 25;277(43):41128-39.
  • [1]. Luberto C, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutralsphingomyelinase. J Biol Chem. 2002 Oct 25;277(43):41128-39.
  • [2]. Essandoh K, et al. Blockade of exosome generation with GW4869 dampe

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Sphingomyelinase (neutral) - R to Z
  1. Medical Research Areas
  2. Metabolism
  3. Phospholipase  (磷脂酶)

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