(R)-6-(Amino(4-Chlorophenyl)(1-Methyl-1H-Imidazol-5-Yl)Methyl)-4-(3-Chlorophenyl)-1-Methylquinolin-2(1H)-One (R)-6-(氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基)-4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮

CAS 192185-72-1 MFCD07772347

化学结构图

192185-72-1
SMILES: Cn1cncc1C(N)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C

化学属性

Mol. FormulaC27H22Cl2N4O
Mol. Weight489.4

别名和识别编码

Chemical Name(R)-6-(Amino(4-Chlorophenyl)(1-Methyl-1H-Imidazol-5-Yl)Methyl)-4-(3-Chlorophenyl)-1-Methylquinolin-2(1H)-One
CAS Number192185-72-1
Synonym (R)-(+)-R 115777 (R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone 2 (1H))-quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-,(+)- 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone R 115777 R-115777 R115777 Zarnestra tipifarnib
Chemical Name Translation(R)-6-(氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基)-4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮
PubChem Substance ID159324
InChIInChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
LabNetwork Molecule IDLN01301159
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分类

  • Amines
  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Tyrosine Kinase Inhibitors

产品应用

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相关文献及参考

  • [2]. Martin LA, et al. The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with ICI 47699 acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo. Mol Cancer Ther. 2007 Sep;6(9):2
  • [3]. End DW, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001 Jan 1;61(1):131-7
  • [4]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.
  • David, E., et al.: Blood, 116, 5285 (2010); Nagai, T., et al.: Leukemia Res., 34, 1057 (2010); Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)
  • [1]. Devendra S Puntambekar, et al. Inhibition of farnesyltransferase: a rational approach to treat cancer? J Enzyme Inhib Med Chem. 2007 Apr;22(2):127-40.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Farnesyl Transferase  (法尼基转移酶)

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