5-(4-Fluorophenyl)-2-Urea Thiophene-3-Formamide 5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺

CAS 507475-17-4 MFCD09037541

化学结构图

507475-17-4
SMILES: NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(N)=O

化学属性

Mol. FormulaC12H10FN3O2S
Mol. Weight279
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name5-(4-Fluorophenyl)-2-Urea Thiophene-3-Formamide
Synonym GW683965 GW683965 GW683965A [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide GW683965A TPCA-1 TPCA1; TPCA 1; TPCA1 [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide
MDL NumberMFCD09037541
PubChem Substance ID329826675
CAS Number507475-17-4
Chemical Name Translation5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺
FormulaC12H10FN3O2S
IUPAC Name5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide
InChIKeySAYGKHKXGCPTLX-UHFFFAOYSA-N
InChIInChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
Canonical SMILESO=C(C1=C(NC(N)=O)SC(C2=CC=C(F)C=C2)=C1)N
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, I Kappa B Kinase (IKK), Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, I Kappa B Kinase (IKK), Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • TPCA-1 is a potent IKK-2 inhibitor. TPCA-1 is also an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation in vivo. It selectively repressed proliferation of NSCLC cells with constitutive STAT3 activation. TPCA-1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF-κB and STAT3 pathways for lung cancers harboring mutant EGFR. Therefore, synergistic treatment of TPCA-1 with TKIs has potential to be a more effective strategy for cancers.

安全信息

GHS Symbol
Precautionary statements
  • P301+P312+P330
  • P305+P351+P338
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xn
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. GlaxoSmithKline - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. NF-kB
  3. IκB/IKK
  1. Medical Research Areas
  2. NF-kB
  3. NF-κB

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