6-Methyl-1’-(2-(5-Methyl-2-Phenyloxazol-4-Yl)Ethyl)Spiro[Benzo[D][1,3]Oxazine-4,4’-Piperidin]-2(1H)-One 6-甲基-1,1’-[2-(5-甲基-2-苯基-4-恶唑基)乙基]-螺[4H-3-1,1-苯并恶嗪-4,4’-哌啶]-2(1H)-酮

CAS 300816-15-3 MFCD09038564

化学结构图

300816-15-3
SMILES: Cc1ccc2c(c1)C1(CCN(CCc3nc(-c4ccccc4)oc3C)CC1)OC(=O)N2

化学属性

Mol. FormulaC25H27N3O3
Mol. Weight417.506

别名和识别编码

Chemical Name6-Methyl-1’-(2-(5-Methyl-2-Phenyloxazol-4-Yl)Ethyl)Spiro[Benzo[D][1,3]Oxazine-4,4’-Piperidin]-2(1H)-One
Chemical Name Translation6-甲基-1,1’-[2-(5-甲基-2-苯基-4-恶唑基)乙基]-螺[4H-3-1,1-苯并恶嗪-4,4’-哌啶]-2(1H)-酮
PubChem Substance ID9953769
InChIInChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)
LabNetwork Molecule IDLN00189860
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相关文献及参考

  • [2]. Yang, Dong., et al. Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury. Respiratory Physiology & Neurobiology (2010), 170(3), 253-259.
  • [3]. Kitagawa, Kiyoki., et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. American Journal of Pathology (2004), 165(1), 237-246.
  • [4]. Tominaga T, et al. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8.
  • [5]. Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
  • [1]. Baamonde, Ana., et al. Involvement of glutamate NMDA and AMPA receptors, glial cells and IL-1β in the spinal hyperalgesia evoked by the chemokine CCL2 in mice. Neuroscience Letters

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. CCR  (趋化因子受体)

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