Lopinavir Metabolite M-1

CAS 192725-39-6 MFCD09840842

化学结构图

192725-39-6
SMILES: CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCC(=O)NC1=O

化学属性

Mol. FormulaC37H46N4O6
Mol. Weight642.78

别名和识别编码

Chemical NameLopinavir Metabolite M-1
CAS Number192725-39-6
Synonym (?S)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-?-(1-methylethyl)-2,4-dioxo-1(2H)-pyrimidineacetami-
Chemical Name Translation
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分类

  • Metabolites & Impurities
  • Non-nucleoside Reverse Transcriptase
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A major metabolite of Lopinavir (L469480) .

相关文献及参考

  • [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.
  • Molla, A., et al.: J. Virology, 250, 255
  • [1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.
  • [1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.
  • [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. HIV Protease  (HIV蛋白酶)

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