Armodafinil

CAS 112111-43-0 MFCD09841055

化学结构图

112111-43-0
SMILES: NC(=O)C[S@@](=O)C(c1ccccc1)c1ccccc1

化学属性

Mol. FormulaC15H15NO2S
Mol. Weight273.3501
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameArmodafinil
CAS Number112111-43-0
Synonym (-)-Modafinil (R)-(-)-Modafinil (R)-Modafinil; 2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide, CEP 10952, CRL 40982, Nuvigil 2-[(R)-(diphenylmethyl)sulfinyl]acetamide Armodafinil CEP-10953; CEP 10953; CEP10953; CRL 40982; CRL-40982; CRL40982; Armodafinil; brand name: Nuvigil.
MDL NumberMFCD09841055
PubChem Substance ID329825109
FormulaC15H15NO2S
IUPAC Name2-[(R)-(diphenylmethyl)sulfinyl]acetamide
InChIKeyYFGHCGITMMYXAQ-LJQANCHMSA-N
InChIInChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1
Canonical SMILESO=C(N)C[S@](C(C1=CC=CC=C1)C2=CC=CC=C2)=O
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分类

  • {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Neurobiology, Neuroscience, Pharmacologicals, Stimulants, Teva, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Pharmacologicals, Stimulants, Teva
  • Chiral Reagents
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Armodafinil is discontinued (DEA controlled substance). Armodafinil, also known as CEP-10953, is the R-enantiomer of the racemic synthetic agent Modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. Armodafinil appears to inhibit the reuptake of dopamine by binding to the dopamine-reuptake pump, which leads to an increase in extracellular dopamine levels in some brain regions. This agent does not bind to or inhibit several receptors and enzymes that may be involved in sleep/wake regulation and is not a direct- or indirect-acting dopamine receptor agonist.

相关文献及参考

  • Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989),
  • Chemelli, R.M., et al.: Cell, 98, 437 (1999),

安全信息

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
WGK Germany3
Signal word Danger
Hazard Codes Xi
Risk Statements
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Restrict {} 精神药品 精麻类化学品
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Teva - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor
  1. Medical Research Areas
  2. Neuronal Signaling
  3. Dopamine Receptor

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