Alcaftadine 阿卡他定
CAS 147084-10-4 MFCD09954106
化学结构图
SMILES: CN1CCC(=C2c3ccccc3CCn3c(C=O)cnc32)CC1
化学属性
| Mol. Formula | C19H21N3O |
|---|---|
| Mol. Weight | 307.38954 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO. |
别名和识别编码
| Chemical Name | Alcaftadine |
|---|---|
| CAS Number | 147084-10-4 |
| Synonym | 6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine-3-carboxaldehyde R 89674 R89674; R 89674; R-89674; Alcaftadine; trade name: Lastacaft; |
| Chemical Name Translation | 阿卡他定 |
| LabNetwork Molecule ID | LN01284787 |
| Formula | C19H21N3O |
| IUPAC Name | 2-(1-Methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0(3,7)]tetradeca- 1(14),3,5,10,12-pentaene-6-carbaldehyde |
| InChIKey | MWTBKTRZPHJQLH-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3 |
| Canonical SMILES | O=CC1=CN=C2/C(C3=CC=CC=C3CCN12)=C4CCN(C)CC/4 |
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分类
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Alcaftadine is used to prevent eye irritation brought on by allergic conjunctivitis. It is a H1 histamine receptor antagonist. It was approved by the U.S. Food and Drug Administration in 2010 under the trade name Lastacaft. Alcaftadine is an antagonist at three of the histamine receptors (1, 2 and 4). The main indication for Alcaftadine is for prevention of allergic conjunctivitis. By blocking these four receptors, Alcaftadine has been shown to significantly reduce the effects of allergens.
相关文献及参考
- [2]. Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32.
- Greiner, J.V. et al.: Clin. Ophthamol., 5, 87 (2011); Torkildsen, G. et al.: Curr. Med. Res. Opin., 27, 623 (2011); Bohets, H. et al.: J. Ocular Pharmcol. Therap., 27, 187 (2011);
- [1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90.
- [1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90.
- [2]. Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32.
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