Prinaberel 普林贝瑞

CAS 524684-52-4 MFCD09954141

化学结构图

524684-52-4
SMILES: C=Cc1cc(O)cc2nc(-c3ccc(O)c(F)c3)oc12

化学属性

Mol. FormulaC15H10FNO3
Mol. Weight271.24

别名和识别编码

Chemical NamePrinaberel
CAS Number524684-52-4
Synonym 2-(3-Fluoro-4- 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol Prinaberel WAY-202041 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol; WAY-202041; Prinaberel 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol ERB 041 ERB-041 ERB041
MDL NumberMFCD09954141
PubChem Substance ID656954
Chemical Name Translation普林贝瑞
InChIInChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,18-19H,1H2
LabNetwork Molecule IDLN01297611
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分类

  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, E, Estrogen, Hormones, Pfizer Compounds, Steroid Hormones
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Diversification Ready Pharma-Developed Compounds, E, Estrogen, Hormones, Pfizer Compounds, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • ERB 041 is a potent ER? agonist; displays >200-fold selectivity for ER? over ER? (IC50 values are 5 and 1216 nM for human ER? and ER?; 3.1 and 620 nM for rat ER? and ER?; and 3.7 and 750 nM for mouse

相关文献及参考

  • Harris, et al.: Endocrinology, 144. 4241 (2003); Malamas, et al.: J. Med. Chem., 47, 5021 (2004); Cvoro, et al.: J. Immunol., 180, 630 (2008),
  • Catley MC, Birrell MA, Hardaker EL, de Alba J, Farrow S, Haj-Yahia S, Belvisi MG.,, "Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease." J. Pharmacol. Exp. Ther. 1 , 83-8, (2008)
  • Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, Staub RE, Baggett S, Herber CB, Griffin C, et. al., Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS ONE 7 , (2009)
  • Cvoro A, Tatomer D, Tee MK, Zogovic T, Harris HA, Leitman DC., "Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes." J. Immunol. 1 , 630-6, (2008) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P305+P351+P338
  • P330 Rinse mouth. 漱口
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xn
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Estrogen - Steroid Hormones

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