Ticagrelor 替卡格雷

CAS 274693-27-5 MFCD09954148

化学结构图

274693-27-5
SMILES: CCCSC1N=C(N[C@@H]2C[C@H]2C2=CC(F)=C(F)C=C2)C2N=NN([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)C=2N=1 |&1:8,10,23,25,30,32|

化学属性

Mol. FormulaC23H28F2N6O4S
Mol. Weight523
Melting Point149-154

别名和识别编码

Chemical NameTicagrelor
CAS Number274693-27-5
Synonym (1S,2S,3R,5S)-
Chemical Name Translation替卡格雷
LabNetwork Molecule IDLN00192701
MDL Number
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndrom

相关文献及参考

  • [2]. Gebremeskel S, et al. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer. 2015 Jan 1;136(1):234-40.
  • [3]. Sugidachi A, et al. A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats. Br J Pharmacol. 2013 May;169(1):82-9.
  • Matetzky, S., et al.: Circulation, 109, 3171
  • [1]. Aungraheeta R, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 Dec 8;128(23):2717-2728.
  • [1]. Aungraheeta R, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 Dec 8;128(23):2717-2728.
  • [2]. Gebremeskel S, et al. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer.

安全信息

GHS Symbol
Safety Statements
Precautionary statements

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. P2Y Receptor  (P2Y受体)

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