N-(3-Methoxy-5-Methylpyrazin-2-Yl)-2-(4-[1,3,4-Oxadiazol-2-Yl]Phenyl)Pyridine-3-Sulfonamide N-(3-甲氧基-5-甲基吡嗪-2-基)-2-(4-[1,3,4-恶二唑-2-基]苯基)吡啶-3-磺酰胺

CAS 186497-07-4 MFCD09955343

化学结构图

186497-07-4
SMILES: COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(-c2nnco2)cc1

化学属性

Mol. FormulaC19H16N6O4S
Mol. Weight424.43
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameN-(3-Methoxy-5-Methylpyrazin-2-Yl)-2-(4-[1,3,4-Oxadiazol-2-Yl]Phenyl)Pyridine-3-Sulfonamide
Chemical Name TranslationN-(3-甲氧基-5-甲基吡嗪-2-基)-2-(4-[1,3,4-恶二唑-2-基]苯基)吡啶-3-磺酰胺
FormulaC19H16N6O4S
Synonym ZD4054; ZD-4054; ZD 4054; Zibotentan.
IUPAC Name2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide
InChIKeyFJHHZXWJVIEFGJ-UHFFFAOYSA-N
InChIInChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
Canonical SMILESO=S(C1=CC=CN=C1C2=CC=C(C3=NN=CO3)C=C2)(NC4=NC=C(C)N=C4OC)=O
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产品应用

  • An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.

相关文献及参考

  • [2]. Laura Rosanò, et al. Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells. Clin Cancer Res. 2011 Apr 15;17(8):2350-60.
  • [3]. Laura Rosanò, et al. ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo. Mol Cancer Ther. 2007 Jul;6(7):2003-11.
  • [1]. C D Morris, et al. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence. Br J Cancer. 2005 Jun 20;92(12):2148-52.
  • [1]. C D Morris, et al. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence. Br J Cancer. 2005 Jun 20;92(12):2148-52.
  • [2]. Laura Rosanò, et al. Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells. Clin Cancer Res. 2011 Apr

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FAK
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. FAK
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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