Aliskiren Hemifumarate 阿利克仑半富马酸盐
CAS 173334-58-2 MFCD10566724
化学结构图
SMILES: CC(C)(CNC(=O)[C@@H](C[C@H](O)[C@@H](N)C[C@H](CC1C=C(OCCCOC)C(=CC=1)OC)C(C)C)C(C)C)C(N)=O.CC(C)(CNC(=O)[C@@H](C[C@H](O)[C@@H](N)C[C@H](CC1C=C(OCCCOC)C(=CC=1)OC)C(C)C)C(C)C)C(N)=O.OC(=O)/C=C/C(O)=O
化学属性
| Mol. Formula | C32H55N3O8 |
|---|---|
| Mol. Weight | 609.79 |
别名和识别编码
| Chemical Name | Aliskiren Hemifumarate |
|---|---|
| CAS Number | 173334-58-2 |
| Synonym | (?S,?S,?S,zS)-?-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-?-hydroxy-4-methoxy-3-(3-methoxypropoxy)-?,z-bis(1-methylethyl)benzeneoctanamide Hemifumarate CGP 60536 CGP60536B Rasilez Hemifumarate SP |
| Chemical Name Translation | 阿利克仑半富马酸盐 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Amines
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
相关文献及参考
- [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.
- [3]. Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705.
- [4]. Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018.
- Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002),
- Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000),
- Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003),
- [1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhi
- [1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754-758
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