Luteinizing hormone-releasing factor (pig),6-(O-1,1-dimethylethyl)-D-serene)-10- deglycinamide-,2-(aminocarbonyl)hydrazide

CAS 65807-02-5 MFCD11044942

化学结构图

65807-02-5
SMILES: [2H][C@@]1(NC(=O)C([2H])([2H])C1([2H])[2H])C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2C=CC=CC1=2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O

化学属性

Mol. FormulaC59H84N18O14
Mol. Weight1269.61

别名和识别编码

Chemical NameLuteinizing hormone-releasing factor (pig),6-(O-1,1-dimethylethyl)-D-serene)-10- deglycinamide-,2-(aminocarbonyl)hydrazide
Synonym Decapeptide I Goserelin D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH ICI 118630 Zoladex
CAS Number65807-02-5
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相关文献及参考

  • [2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32.
  • [1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042.
  • [1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042.
  • [2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32.

安全信息

RTECSOK6369800 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 51 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
   Sense Organs and Special Senses (Eye) - diplopia
   Nutritional and Gross Metabolic - other changes
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 345,458,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Endocrine - androgenic
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 10,478,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 10,478,1989

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. GnRH Receptor  (促性腺激素释放激素受体)

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