MOZAVAPTAN HYDROCHLORIDE
CAS 138470-70-9 MFCD11111965
化学结构图
SMILES: Cl.CN(C)C1CCCN(C2C=CC=CC=21)C(=O)C1C=CC(=CC=1)NC(=O)C1C=CC=CC=1C
化学属性
| Mol. Formula | C27H29N3O2· HCl |
|---|---|
| Mol. Weight | 464.00 |
别名和识别编码
| Chemical Name | OPC 31260 hydrochloride |
|---|---|
| Synonym | 5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride 5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride Mozavaptan hydrochloride N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride Mozavaptan hydrochloride N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride |
| MDL Number | MFCD11111965 |
| CAS Number | 138470-70-9 |
| PubChem Substance ID | 329818895 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Hormones, O, Pituitary Hormones, Vasopressin, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones, Vasopressin
相关文献及参考
- [2]. Yamaguchi K, et al. Clinical implication of the antidiuretic hormone (ADH) receptor antagonist mozavaptan hydrochloride in patients with ectopic ADH syndrome. Jpn J Clin Oncol. 2011 Jan;41(1):148-52.
- Bie, P., et al., Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296 , 428-435, (2009)
- Torres, V.E., Role of vasopressin antagonists. Clin. Nephrol. 3 , 1212-1218, (2008)
- Yeung, P.K., et al., Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality. J. Cereb. Blood Flow Metab. 29 , 1891-1902, (2009) 摘要
- [1]. Yamamura Y, et al. Characterization of a novel aquaretic agent, OPC-31260, a
- [1]. Yamamura Y, et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. Br J Pharmacol. 1992 Apr;105(4):787-91.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
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