RS-127445 hydrochloride
CAS 199864-86-3 MFCD11112196
化学结构图
SMILES: Cl.CC(C)C1C=C(N=C(N)N=1)C1C=CC(F)=C2C=CC=CC=12
化学属性
| Mol. Formula | C17H16FN3· HCl |
|---|---|
| Mol. Weight | 317.79 |
别名和识别编码
| Chemical Name | RS-127445 hydrochloride |
|---|---|
| Synonym | 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride RS-127445 hydrochloride |
| MDL Number | MFCD11112196 |
| Chemical Name Translation | |
| PubChem Substance ID | 329824019 |
| CAS Number | 199864-86-3 |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives,
相关文献及参考
- [2]. Bassil AK, et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol. 2009 Sep;158(1):252-8
- [1]. Bonhaus DW, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol. 1999 Jul;127(5):1075-82.
- [1]. Bonhaus DW, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol. 1999 Jul;127(5):1075-82.
- [2]. Bassil AK, et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol. 2009 Sep;158(1):252-8
安全信息
GHS Symbol
- P301+P310
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
- R36 Irritating to eyes 刺激眼睛
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