(R)-4-Acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one (R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-环己基-3-羟基-1,5-二氢-2H-吡咯-2-酮

CAS 512177-83-2 MFCD11616183

化学结构图

512177-83-2
SMILES: CC(=O)C1[C@@H](C2CCCCC2)N(C2C=CC(Cl)=CC=2F)C(=O)C=1O

化学属性

Mol. FormulaC18H19ClFNO3
Mol. Weight351.803

别名和识别编码

Chemical Name(R)-4-Acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
Chemical Name Translation(R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-环己基-3-羟基-1,5-二氢-2H-吡咯-2-酮
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相关文献及参考

  • [2]. Zweemer AJ, et al. Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2. Mol Pharmacol. 2014 Oct;86(4):358-68.
  • [3]. Zheng Y, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 Dec 15;540(7633):458-461.
  • [1]. Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013 Oct;84(4):551-61.
  • [1]. Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013 Oct;84(4):551-61.
  • [2]. Zweemer AJ, et al. Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2. Mol Pharmacol. 2014 Oct;86(4):358-68.
  • [3]. Zheng Y, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 Dec 15;540(7633):458-461.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. CCR  (趋化因子受体)

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