[4,5-bis(hydroxymethyl)-2-methylpyridin-3-yl]methanol hydrochloride 5-羟基-6-甲基-3,4-二羟甲基吡啶盐酸盐

CAS 58-56-0 MFCD00012807

化学结构图

58-56-0
SMILES: Cc1ncc(CO)c(CO)c1O.Cl

化学属性

Mol. FormulaC8H11NO3.HCl
Mol. Weight206
Melting Point214-215
TSCAYes
Solubility0.1 G/ML (20 ºC)
Stability对光线敏感

别名和识别编码

Chemical Name[4,5-bis(hydroxymethyl)-2-methylpyridin-3-yl]methanol hydrochloride
MDL NumberMFCD00012807
CAS Number58-56-0
Synonym Vitamin B6 hydrochloride 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride Pyridoxinum hydrochloricum Adermin Hydrochloride 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride 吡哆辛盐酸盐, 99% PN HCl 吡哆醇 盐酸盐 抗皮炎素 盐酸盐 维生素 B6 盐酸盐 维生素B6 Hexavibex PN HCl Pyridoxine HCl 吡哆醇 盐酸盐 抗皮炎素 盐酸盐 维生素 B6 盐酸盐 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride Hexabetalin Becilan 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
PubChem Substance ID6019
Beilstein Registry Number3632435
EC Number200-386-2
Merck Number7982
Reaxys-RN3632435
Chemical Name Translation5-羟基-6-甲基-3,4-二羟甲基吡啶盐酸盐
Wiswesser Line NotationT6NJ B1 CQ D1Q E1Q &GH
LabNetwork Molecule IDLN00223476
InChIInChI=1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
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分类

  • {SNA} Analytical Stan
  • {SNA} Core Bioreagents, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Vitamins and Supplements, Research Essentials, Vitamin B, Vitamin B6, Vitamins, Vitamins and Coenzymes, 分析/色谱, 细胞生物学, 营养研究
  • {SNA} Companion Products and Reagents, Core Bioreagents, Insect Platform, Research Essentials, Vitamin B, Vitamin B6, Vitamins, Vitamins and Coenzymes, 无血清培养基, 细胞培养, 细胞生物学, 营养研究
  • {SNA} Analytical Standards,
  • {SNA} Core Bioreagents, Research Essentials, Vitamin B,

产品应用

  • 生化研究。

相关文献及参考

  • Merck:14,7982
  • Merck:14,7982 Beilstein: 21,V,5,492
  • [1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

安全信息

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSUV1350000
Storage condition Light Sensitive 密封阴凉干燥保存。 储存温度2-8℃
Hazard Codes Xi
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Signal word Danger
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
  • H303 May be harmfully swallowed 吞食可能有害
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
GHS Symbol 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 560 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,1961

TYPE OF TEST

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 124,175,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 37,447,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 gm/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   66,198,1992

TYPE OF TEST            : TDL

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   66,198,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 39,159,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 gm/kg
SEX/DURATION            : male 2 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epi

其他信息

  • 无气味。味微咸苦。遇光渐变质。在空气中稳定。1g溶于约4.5ml水、90ml乙醇，微溶于丙酮，不溶于乙醚和氯仿。10%水溶液pH3.2。酸性水溶液稳定，即便在加热至120℃(分解并升华)。最大吸收波长(0.1mol/L盐酸)290nm(ε840)、(磷酸盐缓冲，pH7)253、325nm(ε3700、7100)。低毒，半数致死量(大鼠，经口)4000mg/kg。

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Vitamins and Coenzymes - Core Bioreagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PU - PZ - P
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin B - Vitamins
  5. Vitamin B6 - Vitamin B
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Pyridinium Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Vitamins
  4. Vitamin B5
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)