Rivaroxaban 利伐沙班

CAS 366789-02-8 MFCD11974010

化学结构图

366789-02-8
SMILES: O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1

化学属性

Mol. FormulaC19H18ClN3O5S
Mol. Weight436
Appearance XXXX solid powder
SolubilitySoluble in DMSO.

别名和识别编码

Chemical NameRivaroxaban
CAS Number366789-02-8
Alfabeta NameCHLOROOXOOXOMORPHOLINOPHENYLOXAZOLIDINYLMETHYLTHIOPHENECARBOXAMIDE SN5234352((((()))))--------------
MDL NumberMFCD11974010
Synonym 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide BAY 59-7939 BAY59-7939; BAY 59-7939; BAY-59-7939; Rivaroxaban; trade name: Xarelto.
Chemical Name Translation利伐沙班
LabNetwork Molecule IDLN00177401
FormulaC19H18ClN3O5S
IUPAC Name(S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
InChIKeyKGFYHTZWPPHNLQ-AWEZNQCLSA-N
InChIInChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
Canonical SMILESO=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=CC=C(N4C(COCC4)=O)C=C3)C(O2)=O
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds,

产品应用

  • Rivaroxaban, also known as BAY 59-7939, is an oral anticoagulant invented and manufactured by Bayer; in a number of countries it is marketed as Xarelto. If approved by the United States FDA, it will be marketed by Ortho-McNeil Pharmaceutical. It is the first available orally active direct factor Xa inhibitor. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa occurs four hours after a dose. The effects lasts 8–12 hours, but factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible.

相关文献及参考

  • Ansell, J., et al.: Drugs, 64, 1 (2004),
  • Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005),
  • Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),

安全信息

Warnings IRRITANT
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Factor Xa

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