2-Chloro-5-(2-Phenyl-4-(Pyridin-4-Yl)-1H-Imidazol-5-Yl)Phenol 2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-5-基)苯酚

CAS 303727-31-3 MFCD12828750

化学结构图

303727-31-3
SMILES: Oc1cc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)ccc1Cl

化学属性

Mol. FormulaC20H14ClN3O
Mol. Weight347.8
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name2-Chloro-5-(2-Phenyl-4-(Pyridin-4-Yl)-1H-Imidazol-5-Yl)Phenol
CAS Number303727-31-3
Synonym 2-Chloro-5-[2-phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol 4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-imidazole L779450; L-779450; L 779450; L779,450; L 779,450; L-779,450.
Chemical Name Translation2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-5-基)苯酚
FormulaC20H14ClN3O
IUPAC Name2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol
InChIKeyWXJLXRNWMLWVFB-UHFFFAOYSA-N
InChIInChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
Canonical SMILESOC1=CC(C2=C(C3=CC=NC=C3)NC(C4=CC=CC=C4)=N2)=CC=C1Cl
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分类

  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • L-779450 is a potent, selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM). L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

相关文献及参考

  • Takle, A., et al.: Bioorg. Med. Chem. Lett., 16, 378 (2006),
  • Zhu, T., et al.: Bioorg. Med. Chem. Lett., 18, 2346 (2008),

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. MARK
  3. Raf

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