(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone (2S)-1-(3,4-二氢-6,7-二甲氧基-2(1H)-苏喹啉基)-3,3-二甲基-2-[(4-吡啶基甲基)氨基]-1-丁酮

CAS 372523-75-6 MFCD12828766

化学结构图

372523-75-6
SMILES: COc1cc2c(cc1OC)CN(C(=O)C(NCc1ccncc1)C(C)(C)C)CC2

化学属性

Mol. FormulaC23H31N3O3.ClH
Mol. Weight433.977

别名和识别编码

Chemical Name(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone
Chemical Name Translation(2S)-1-(3,4-二氢-6,7-二甲氧基-2(1H)-苏喹啉基)-3,3-二甲基-2-[(4-吡啶基甲基)氨基]-1-丁酮
PubChem Substance ID10408514
InChIInChI=1S/C23H31N3O3/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3/t21-/m1/s1
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相关文献及参考

  • [2]. Tabaeizadeh M, et al. The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice. Behav Brain Res. 2013 Jan 15;237:41-8.
  • [3]. R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363.
  • [1]. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9.
  • [1]. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9.
  • [2]. Tabaeizadeh M, et al. The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice. Behav Brain Res. 2013 Jan 15;237:41-8.
  • [3]. R

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Orexin Receptor (OX Receptor)  (食欲素受体)

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