1-Tert-Butyl-3-[6-(2,6-Dichlorophenyl)-2-[[4-(Diethylamino)Butyl]Amino]Pyrido[2,3-D]Pyrimidin-7-Yl]Urea 1-(叔丁基)-3-(6-(2,6-二氯苯基)-2-((4-(二乙基氨基)丁基)氨基)吡啶并[2,3-D]嘧啶-7-基)脲

CAS 192705-80-9 MFCD16618403

化学结构图

192705-80-9
SMILES: CC(C)(C)NC(=O)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C1C(Cl)=CC=CC=1Cl

化学属性

Mol. Weight532.51
Mol. FormulaC26H35Cl2N7O

别名和识别编码

Synonym 1-tert-Butyl-3-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea 1-tert-Butyl-3-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea PF-1480232 PF-1480232
MDL NumberMFCD16618403
CAS Number192705-80-9
Chemical Name1-Tert-Butyl-3-[6-(2,6-Dichlorophenyl)-2-[[4-(Diethylamino)Butyl]Amino]Pyrido[2,3-D]Pyrimidin-7-Yl]Urea
PubChem Substance ID329823701
Chemical Name Translation1-(叔丁基)-3-(6-(2,6-二氯苯基)-2-((4-(二乙基氨基)丁基)氨基)吡啶并[2,3-D]嘧啶-7-基)脲
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分类

  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Fibroblast Growth Factor Receptor (FGFR), Kinase/Phosphatase Biology, P, Pfizer Compounds, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Fibroblast Growth Factor Receptor (FGFR), Kinase/Phosphatase Biology, P-PH, Pfizer Compounds, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • Batley., et al., Inhibition of FGF-1 receptor tyrosine kinase activity by PD-161570, a new protein-tyrosine kinase inhibitor. Life Sci. 62 , 143-150, (1998) 摘要
  • Stevens DA., et al., hyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol. Endocrinol. 17 , 1751-1766, (2003)
  • Hamby, James M., et al., Structure-Activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J. Med. Chem. 40 , 2296-2303, (1997)

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Fibroblast Growth Factor Receptor (FGFR) - Receptor Tyrosine Kinase Inhibitors

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