SB 277011 Hydrochloride
CAS 215804-67-4 MFCD15804674
化学结构图
SMILES: N#CC1C=C2CCN(CC2=CC=1)CC[C@@H]1CC[C@H](CC1)NC(=O)C1=CC=NC2C=CC=CC=21 |&1:14,17|
化学属性
| Mol. Weight | 475.02 |
|---|---|
| Mol. Formula | C28H31ClN4O |
别名和识别编码
| CAS Number | 215804-67-4 |
|---|---|
| Chemical Name | SB 277011 Hydrochloride |
| Synonym | N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]- |
| Chemical Name Translation |
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分类
- Amines
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A potent and selective dopamine D3 receptor antagonist.
相关文献及参考
- [2]. Rui Song, et al. YQA14: A Novel Dopamine D3 Receptor Antagonist That Inhibits Cocaine Self-Administration in Rats and Mice, but Not in D3 Receptor-Knockout Mice. Addict Biol
- Sokoloff, P., et al.: Nature, 347, 146
- [1]. Stemp G, et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat. J Med Chem. 2000 May 4;43(9):1878-85.
- [1]. Stemp G, et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat. J Med Chem. 2000 May 4;43(9):1878-85.
- [2]. Rui Song, et al. YQA14: A Novel Dopamine D3 Receptor Antagonist That Inhibits Cocaine Self-Administration
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