JZL 195 4-(3-苯氧基苄基)哌嗪-1-甲酸对硝基苯酯

CAS 1210004-12-8 MFCD18382122

化学结构图

1210004-12-8
SMILES: [O-][N+](=O)C1C=CC(=CC=1)OC(=O)N1CCN(CC2C=C(C=CC=2)OC2C=CC=CC=2)CC1

化学属性

Mol. Weight433.46
Mol. FormulaC24H23N3O5

别名和识别编码

Synonym 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
MDL NumberMFCD18382122
CAS Number1210004-12-8
Chemical NameJZL 195
PubChem Substance ID329825265
Chemical Name Translation4-(3-苯氧基苄基)哌嗪-1-甲酸对硝基苯酯
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分类

  • {SA} Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Fatty Acid Amide Hydrolase, Neurobiology, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pharmacologicals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cannabinoids, Enzyme Inhibitors, Fatty Acid Amide Hydrolase, J, Neurobiology, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.
  • Long, J.Z., et al,, Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J. Med. Chem. 4 , 1830-1842, (2010)
  • Long, J.Z., et al., Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc. Natl. Acad. Sci. U. S. A. 48 , 20270-20275, (2010)
  • [1]. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.
  • [1]. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.
  • [2]. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in

安全信息

GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
Signal word Warning
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
WGK Germany3
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Hazard Codes N
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitter Metabolism - Neurotransmission
  7. Enzyme Inhibitors - Neurotransmitter Metabolism
  8. Fatty Acid Amide Hydrolase - Enzyme Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. FAAH  (脂肪酰胺水解酶)
  1. Medical Research Areas
  2. Metabolism
  3. MAGL  (单酰甘油酯酶)

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