4,4′-Methylenebis(N,N-Dimethylaniline) 4,4-(对二甲氨基)二苯基甲烷

CAS 101-61-1 MFCD00008317

化学结构图

101-61-1
SMILES: CN(C)c1ccc(Cc2ccc(N(C)C)cc2)cc1

化学属性

Mol. FormulaC17H22N2
Mol. Weight254.38
Density1.066
Melting Point88-89°C
Flash Point178°(352°F)
TSCAYes
Boiling Point390 °C at 760 mmHg
Solubility不溶
Stability对湿度敏感

别名和识别编码

Chemical Name4,4′-Methylenebis(N,N-Dimethylaniline)
CAS Number101-61-1
Synonym Bis(4-(N,N-dimethylamino)phenyl)methane {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)phenyl)methane {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bis(4-(N,N-dimethylamino)ph
EC Number202-959-2
Beilstein Registry Number479956
MDL NumberMFCD00008317
PubChem Substance ID87563515
Merck Number6176
Reaxys-RN479956
Chemical Name Translation4,4-(对二甲氨基)二苯基甲烷
Wiswesser Line Notation1N1&R D1R DN1&1
LabNetwork Molecule IDLN00193520
InChIInChI=1S/C17H22N2/c1-18(2)16-9-5-14(6-10-16)13-15-7-11-17(12-8-15)19(3)4/h5-12H,13H2,1-4H3
Canonical SMILESCN(C)C1=CC=C(CC2=CC=C(C=C2)N(C)C)C=C1
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分类

  • Mutagenesis Research Chemicals
  • {SNA} M, Stains & Dyes, A to Z, Stains and Dyes, 细胞生物学, 血液学和组织学
  • {SA} Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Polyamines
  • {SNA} Cell Biology, Hematology and Histology, M, Stains & Dyes, A to Z, Stains and Dyes
  • {SNA} Hematology and Histology, M, Stains & Dyes, A to Z, Stains and Dyes
  • Amines
  • {SNA} Hematology and Histology, M, Stains & Dyes, A to Z, Stains and Dyes, 细胞生物学
  • Aromatics

产品应用

  • 其盐酸盐作铅试剂,染料中间体,与氧化剂作用时形成深蓝色氧化物检验铅、臭氧及其他氧化剂,沉淀钨。

相关文献及参考

  • Merck:14,6176 Beilstein: 13,IV,390
  • Clewell, H., et al.: Regul. Toxicol. Pharm., 42, 3 (2005),
  • Andersen, M., et al.: Sci. Total Environ., 274, 3 (2001),
  • Edler, L., et al.: Mutat. Res., 405, 227 (1998),
  • Merck:14,6176

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R45 May cause cancer 可能致癌
  • R50/53
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P510
RTECSBY5250000
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H350 May cause cancer 可能致癌
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing GroupIII
UN Number UN3077 UN 3077 9/PG 3
Hazard Codes T,N T,N,Xi
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Class6.1(b)
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7744 mg/kg/59W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 72,1457,1984

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 164 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-186,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8500 mg/kg/59W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-186,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 82 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-186,1979

TYPE OF TEST

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 90,260,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12(Suppl 13),103,1988

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION           : 125 mg/kg
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,911,1979

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rabbit Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,197,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 100 ug/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 19,642,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,359,1982

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211

其他信息

  • 上游原料:乙酸 --> 甲酸 --> N,N-二甲基苯胺 --> 多聚甲醛
  • 用途一:用作染料中间体及测定铅、锰、臭氧等的灵敏试剂
  • Sigma Aldrich:101-61-1(sigmaaldrich)
  • 概述:4'4 - 四甲基二氨基二苯甲烷常温下为白色或淡蓝白色片状结晶,能升华而不分解,易溶于热醇,能溶于醚、苯、二硫化碳及酸类,不溶于水,不能随水蒸气一同挥发 。
  • 用途二:其盐酸盐作铅试剂,染料中间体,与氧化剂作用时形成深蓝色氧化物检验铅、臭氧及其他氧化剂,沉淀钨。
  • Alfa Aesar:4,4'-亚甲基二(N,N-二甲基苯氨),98+% 4,4'-Methylenebis(N,N-dimethylaniline), 98+%(101-61-1)
  • TCI Shanghai:二(4,-二甲氨基苯基)甲烷 Bis[4-(dimethylamino)phenyl]methane,>;98.0%(GC)(T)(101-61-1)
  • 能升华而不分解。易溶于热醇,能溶于醚、苯、二硫化碳及酸类,不溶于水。
  • 海关编码:29215990
  • 4,4'-(对二甲氨基)二苯基甲烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B0483 双[4-(二甲氨基)苯基]甲烷 Bis[4-(dimethylamino)phenyl]methane 25G 293元 2014/06/02 B0483 双[4-(二甲氨基)苯基]甲烷 Bis[4-(dimethylamino)phenyl]methane 500G 1460元 2010/06/21 126741000 4,4'-(对二甲氨基)二苯基甲烷 4,4'-Methylenebis(N,N-dimethylaniline) 99+% 100 GR 765元
  • MSDS 信息:4,4'-Methylenebis(N,N-dimethylaniline)(101-61-1).msds
  • Hazard Note:Harmful/Irritant
  • 外观性质:白色或淡蓝白色片状结晶。能升华而不分解。易溶于热醇,能溶于醚、苯、二硫化碳及酸类,不溶于水。熔点:91 °C沸点:390 °C 闪点:178 °C
  • 图谱信息:4,4'-(对二甲氨基)二苯基甲烷(101-61-1)质谱(MS) 4,4'-(对二甲氨基)二苯基甲烷(101-61-1)核磁图( 13 CNMR) 4,4'-(对二甲氨基)二苯基甲烷(101-61-1)红外图谱(IR1) 4,4'-(对二甲氨基)二苯基甲烷(101-61-1)Raman光谱 4,4'-(对二甲氨基)二苯基甲烷(101-61-1)红外图谱(IR2) 4,4'-(对二甲氨基)二苯基甲烷(101-61-1)核磁图( 1 HNMR)
  • MOL 文件:101-61-1.mol
  • Acros Organics:4,4'-甲基双(N,N-二甲苯胺) 4,4'-Methylenebis(N,N-dimethylaniline), 99+%(101-61-1)

系列性分类


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