TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 180,155,1969

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,375,1962

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraduodenal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 670 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 180,155,1969

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 203 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/yea

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 pph/5H
REFERENCE :
   HUMAA7 Humangenetik.  (Heidelberg, Fed. Rep. Ger.)  V.1-30, 1964-75.  For
   publisher information, see HUGEDQ.  Volume(issue)/page/year: 4,371,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 1959-76.  For
   publisher information, see PSCHDL.  Volume(issue)/page/year: 10,44,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2365 mg/kg
SEX/DURATION            : female 10-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   AJBSAM Australian Journal of Biological Sciences.  (Commonwealth Scientific
   and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic.
   3002, Australia)  V.6-    1953-  Volume(issue)/page/year: 35,173,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   PHBHA4 Physiology and Behavior.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1966-  Volume(issue)/page/year:
   4,677,1969

• P201 Obtain special instructions before use. 使用前获取专门指示。
• P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
• P203
• P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
• P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
• P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
• P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
• P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
• P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
• P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
• P281 Use personal protective equipment as required. 使用所需的个人防护装备。
• P284 Wear respiratory protection.? 佩戴呼吸保护装置。
• P301+P310
• P301+P312
• P301+P316
• P301+P317
• P302+P350
• P302+P352
• P304+P340
• P308+P313
• P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
• P316
• P318
• P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
• P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
• P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
• P330 Rinse mouth. 漱口
• P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
• P361+P364
• P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
• P403+P233
• P405 Store locked up. 上锁保管。
• P501 Dispose of contents/container to..… 处理内容物/容器.....

• H300 Fatal if swallowed 吞食致命
• H302 Harmful if swallowed 吞食有害
• H310 Fatal in contact with skin 皮肤接触致命
• H330 Fatal if inhaled 吸入致命
• H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害