• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Reagents, Chemical Synthesis, Development Quantities for Research, Organic Building Blocks
• {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
• {Chemicalbook} 农药中间体: 杀螨剂中间体
• {uni_hamburg} no charge; 1fragment
• {SNA} Chemical Reagents, Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Development Quantities for Research, Organic Building Blocks

产品应用

• 是重要的有机化工原料和中间体，是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪，双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。

相关文献及参考

• Short: II/24C
• Merck: 14,6076
• Reagent for replacement of an activated chlorine in an aromatic or heteroaromatic ring by the methylamino group: Synthesis, 39 (1980).
• Short: II/14a
• Merck: 14,6076 Beilstein:4,58
• Short: II/24B
• Precursor of methyl isocyanide (highly toxic!), by dehydration with tosyl chloride in pyridine: Org. Synth. Coll., 5, 772 (1973).

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - somnolence (general depressed activity)
   Musculoskeletal - other changes
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(2),30,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volu

{hazar

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 802 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 34,173,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   DABBBA Dissertation Abstracts International, B: The Sciences and
   Engineering.  (University Microfilms International, 300 N. Zeeb Rd., Ann
   Arbor, MI 48106)  V.30-    1969-  Volume(issue)/page/year: 40,549,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1557,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted

其他信息

• 上游原料:甲酸 --> 一甲胺 --> 甲酸乙酯 --> 一氧化碳 --> 甲酸甲酯
• {Chem
• 方法二:1.甲胺法由甲胺与一氧化碳反应制得。2.甲酸甲酯法由甲酸甲酯与甲胺反应而得。3.由甲酸乙酯和甲胺反应而得。将甲酸乙酯加入反应器中，在冷却下加入甲胺水溶液，于40℃回流反应。然后放置3d，减压回收乙醇得到粗品。再经减压蒸馏而得成品。
• 毒性分级:中毒
• 灭火剂:泡沫、二氧化碳、雾状水、砂土
• 用途三:用作有机合成原料，用于农药杀虫药剂、医药、合成革、人造革等的合成；以及用作化纤纺织溶剂等。
• 急性毒性:口服- 大鼠 LD50: 4000 毫克/ 公斤; 口服- 小鼠 LD50: 2600 毫克/ 公斤
• 刺激数据:眼睛- 兔子 100 毫克
• 下游产品:双甲眯 --> 2-甲基氨基吡啶
• MOL 文件:123-39-7.mol
• Alfa Aesar:N-甲基甲酰胺,99% N-Methylformamide, 99%(123-39-7)
• Sigma Aldrich
• 有氨味。可与苯互溶，溶于水、醇和丙酮，不溶于醚。
• 用途四:是重要的有机化工原料和中间体，是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪，双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。
• 类别:易燃液体
• 图谱信息:N-甲基甲酰胺(123-39-7)核磁图( 13 CNMR) N-甲基甲酰胺(123-39-7)红外图谱(IR1) N-甲基甲酰胺(123-39-7)核磁图( 1 HNMR) N-甲基甲酰胺(123-39-7)质谱(MS)
• 可燃性危险特性:遇明火、高温、强氧化剂可燃;燃烧排放有毒氮氧化物烟雾
• 方法一:N-甲基甲酰胺主要有以下三种合成工艺。 (1)甲胺法 由甲胺与一氧化碳作用而得。CO+CH 3 NH 2 →HCONHCH 3 将一甲胺69.62％(质量分数)、甲醇29.87％(质量分数)和甲醇钠0.5％(质量分数)(对于一甲胺为0.72％)的混合物向反应器供给87.05kg/h，同时供给含量为99.5％的一氧化碳56.5kg/h，反应温度90℃，压力2.53MPa。每小时取出含一甲胺80.5％(质量分数)的混合物140.75kg，即N-甲基甲酰胺生成量为每小时113.4kg，1L反应器的生产能力为每小时1.89kg N-甲基甲酰胺。 (2)甲酸甲酯法 由甲酸甲酯与甲胺反应而得。 CH 3 NH 2 +HCOOCH 3 →HCONHCH 3 +CH 3 OH 产物经初馏、精馏而得成品，总收率达90％；产品含量95％～99.5％以上。 (3)甲酸乙酯法 由甲酸乙酯和甲胺作用而得。 HCOOC 2 H 5 +CH 3 NH 2 →HCONHCH 3 +C 2 H 5 OH 先将甲酸乙酯加入反应罐中，然后在冷却下加入甲胺水溶液[甲酸乙酯和甲胺水溶液按1∶1.2(mol)配料]，于40℃回流搅拌，然后放置3d，减压回收乙醇，粗品经减压蒸馏而得成品。
• 储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂、酸分开
• TCI Shanghai:N-甲基甲酰胺 N-Methylformamide,>;99.0%(GC)(123-39-7)
• 用途二:N-甲基甲酰胺是一种重要的有机合成原料，用于农药杀虫杀螨剂单甲脒、双甲脒的合成，也用于生产医药、合成革、人造革以及用作化纤纺织溶剂等。
• Acros Organics:N-甲基甲酰胺 N-Methylformamide, 99+%(123-39-7)
• N-甲基甲酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010203 N-甲基甲酰胺;N-甲酰基甲胺 100g 85元 2011/04/16 F0059 N-甲基甲酰胺 N-Methylformamide 25G 175元 2011/04/16 F0059 N-甲基甲酰胺 N-Methylformamide 500G 550元