安全信息
RTECS | ZG0600000 |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 138,78,1962
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 400 ug/kg
SEX/DURATION : female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JNEUAY Journal of Neuropsychiatry. (Chicago, IL) V.1-5, 1959-64. For
publisher information, see BENPBG. Volume(issue)/page/year: 4,87,1962
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 400 ug/kg
SEX/DURATION : female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JNEUAY Journal of Neuropsychiatry. (Chicago, IL) V.1-5, 1959-64. For
publisher information, see BENPBG. Volume(issue)/page/year: 4,87,1962