Phenazocine

CAS 127-35-5 MFCD01715071

化学结构图

127-35-5
SMILES: CC1[C@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCc1ccccc1

化学属性

Mol. FormulaC22H27NO
Mol. Weight321.50

别名和识别编码

Chemical NamePhenazocine [INN:BAN]
CAS Number127-35-5
Synonym (+)2'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-phenylethyl)-2,6-methano-3-benzazocin-8-ol 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-phenethyl-2,6-methano-3-benzazocin-8-ol 1,2,3,4,5,6-Hexahydro-8-hydroxy-6,11-dimethyl-3-phenethyl-2,6-methano-3-benzazocine 2'-Hydroxy-5,9-dimethyl-2-phenethyl- 2'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan 6,11-Dimethyl-1,2,3,4,5,6-hexahydro-8-hydroxy-3-phenethyl-2,6-methano-3-benzazocine Hydrobromide, Phenazocine NIH 7519 Narphen Phenazocine Phenazocine Hydrobromide Phenbenzorphan Phenethylazocine Prinadol SKF 6574
InChIKeyZQHYKVKNPWDQSL-UHFFFAOYSA-N
Wiswesser Line NotationT C666 A KN&TTJ A1 B1 EQ K2R
PubChem Substance ID14707
InChIInChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3
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分类

  • Heterocycles
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • ########

相关文献及参考

  • Hopton, D. et al.: Gut, 12, 51 (1971); Eckenhoff, J.E. et al.: Anesthesiology, 20, 355 (1959); Clarke, E.G. et al.: Nature, 184, 451 (1959);

安全信息

RTECSPB8890000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 29 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NYSJAM New York State Journal of Medicine.  (Medical Soc. of the State of
   New York, POB 5405, Lake Success, NY 11042)  V.1-    1901-
   Volume(issue)/page/year: 61,83,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,309,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 1,1,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02061

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