PolymyxinB,N-sulfomethylderiv.,sodiumsalt 硫酸多黏菌素E

CAS 1407-09-6 MFCD01407096

化学结构图

1407-09-6
SMILES:

化学属性

Mol. FormulaA:C53H100N16O13

别名和识别编码

Chemical NameThiosporin
Chemical Name Translation硫酸多黏菌素E
Chemicalbook IDCB4884547
Synonym Polymyxin B methanesulfonic acid Polymyxin B, N-sulfomethyl deriv., sodium salt Polymyxin B methanesulfonate
CAS Number1407-09-6
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安全信息

RTECSXN6237000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 23,552,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 137 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INURAQ Investigative Urology.  (Baltimore, MD)  V.1-19, 1963-81.  For
   publisher information, see JOURAA.  Volume(issue)/page/year: 6,505,1969

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